SIMPLESCREEN™ CRC TEST RESULTS
Understanding what comes next

SimpleScreen CRC is a blood test that detects DNA signals associated with colon cancer in average-risk adults ages 45 and older. Here’s what you need to know about your results:

  • A positive result does not mean you have colon cancer, but it needs a follow-up colonoscopy
  • Your test result is sent to you and your doctor within 2 weeks, where you can view it in your patient account
  • Regardless of the result, lean on your doctor for next steps
A pair of hands holds a smartphone showing a negative test result onscreen.

What to do after a negative result

Keep getting screened

Continue routine colon cancer screenings every 3 years after a negative result, as advised by the American Cancer Society.1

Your doctor is your ally

As you get older, your screening needs may change. Talk to your provider about your other screening options, including the Cologuard Plus® test, which detects 95% of stage 1 to 4 colon cancers.2

A pair of hands holds a tablet showing a positive result onscreen.
* False negatives and positives can occur. When you discuss your result with a health care provider, ask when you should screen again.

What to do after a positive result

A colonoscopy is required

Reach out to your doctor right away so they can schedule a colonoscopy to help identify the cause of your positive result.

Partner with your doctor for a clear game plan

Discuss your results, and work together to map out a clear path for any future care, treatments, and screening intervals.

A man on a couch uses his tablet to check his test result.
Access your results
Once your blood sample reaches the lab, your result is delivered within 2 weeks. If you haven’t already, sign up for a patient account to access your report easily.
Card List
Screen every 3 years1
Whether you choose a noninvasive blood or stool test, the American Cancer Society recommends screening every 3 years after a negative SimpleScreen CRC or Cologuard Plus test result.
Frequently asked questions

SimpleScreen CRC tests your blood for cancer signals, with results that have shown:

  • 81% cancer detection: Flags 81 out of 100 colorectal cancers, helping with detection and treatment.1
  • 90% specificity: 9 out of 10 people who do not have colon cancer or advanced precancerous lesions get a negative result.1

1SimpleScreen CRC Provider Brochure. Freenome LLC. Brisbane, CA.

A negative SimpleScreen CRC blood test means no DNA signals associated with colon cancer or advanced precancerous lesions were detected. It does not guarantee that you don’t have colon cancer or advanced precancer lesions (APLs). Consult your doctor or care provider about your next steps.

A positive SimpleScreen CRC blood test means that specific DNA patterns have been found in your blood that require further medical evaluation. It is not a cancer diagnosis. Talk to your doctor or provider so they can schedule a colonoscopy for further testing.

Once your blood sample reaches the lab, it’s processed, and your results are delivered to your account within 2 weeks. A copy of your report is sent directly to your provider at the same time. Review your test results with them to develop a plan based on your needs.

Whether you choose a noninvasive blood or stool test, the American Cancer Society recommends screening every 3 years following a negative SimpleScreen CRC result.1

1 ACS. American Cancer Society Guideline for colorectal cancer screening. Updated May 27, 2026. Accessed August 3, 2026. https://www.cancer.org/cancer/types/colon-rectal-cancer/detection-diagnosis-staging/acs-recommendations.html.

Yes. A false positive result occurs when the test produces a positive result even though a colonoscopy will not find colon cancer or advanced precancer lesions (APLs). SimpleScreen CRC has a false-positive rate of 10%. This means 1 out of 10 people who do not have colorectal cancer or advanced precancerous lesions may receive a positive result.1 A positive result should be followed by a colonoscopy because there is an increased chance of colon cancer or an advanced precancerous polyp.

1 SimpleScreen CRC Provider Brochure. Freenome LLC. Brisbane, CA

Yes, a false negative result occurs when the test does not detect colon cancer or advanced precancer lesions (APLs), although a colonoscopy would identify either of these findings. SimpleScreen CRC has a false negative rate of 21% for colorectal cancer, meaning 21 of 100 people who have it will have a false negative result.1

1 SimpleScreen CRC Provider Brochure. Freenome LLC. Brisbane, CA

Log in to your account to access your test result in about 2 weeks of the lab receiving your blood sample. A copy of your report is sent directly to your provider at the same time. Review your test results with your provider to develop a plan based on your needs.

Card List